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doi: 10.3390/jcm10050985 174 UnniSWittbrodtEMaJSchauerhamerMHurdJRuiz-NegrnNet al

In the Phase 2 retatrutide trial published in the New England Journal of Medicine (2023), participants at the highest dose (12 mg) achieved a mean body weight reduction of approximately 24.2% over 48 weeks

This can likely be attributed to the action GLP-1 RAs exert on the central nervous system and brain function.15 While effective at reducing caloric intake, we consider it a side effect, as our testing team generally regarded it as an unpleasant experience

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2023;15(13) doi: 10.3390/nu15132859