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Beyond the outcome data, the large number of participants on concomitant treatment with GLP-1 RA and SGLT2i provides important safety data with no significant differences in serious adverse events in participants with and without SGLT2i use

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Frequently Asked Questions How common are headaches when starting tirzepatide? Headaches occur in 1525% of tirzepatide patients during the first 12 weeks of treatment, with peak incidence between weeks 14 during initial dose escalation