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Azarcan and their collaborators showed that bromelain at 0.3 M induced high mortality in breast adenocarcinoma and melanoma cell lines (36)

NF-kappaB is a negative regulator of IL-1beta secretion as revealed by genetic and pharmacological inhibition of IKKbeta

FIGURE 4 In the context of ferroptosis, COX-2 activation is known to exacerbate inflammation and oxidative damage, thereby driving iron overload (Stockwell et al., 2017)