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Pregnancy Neonatal Opioid Withdrawal Syndrome Inform female patients of reproductive potential that use of hydrocodone bitartrate and acetaminophen tablets for an extended period of time during pregnancy can result in neonatal opioid withdrawal syndrome, which may be life-threatening if not recognized and treated (see WARNINGS and PRECAUTIONS, Pregnancy)

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G.SchoenbergM.JeronimoC.Sanchez-CespedesM.et al (2001)