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However, DON has had difficulty progressing into clinical trials due to concerns regarding its lack of selectivity to GLS and toxicity [110, 113, 114]

Yes but with nuance

This occurs through the regulation of NRF2, a nuclear factor responsible for modulating the expression of genes related to anti-inflammatory responses and cell survival in the vascular endothelium [62]

Insulin has returned to baseline, ghrelin is rising, and somatostatin tone is low

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