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Contact your healthcare team urgently if you experience severe or persistent vomiting, signs of hypoglycaemia or diabetic ketoacidosis, dehydration, severe abdominal pain suggestive of pancreatitis, gallbladder symptoms, or difficulty meeting nutritional needs

Take creatine for example

It was initially scrutinized due to systemic absorption concerns, leading to its placement in Category 2

Malaki M, Xu W, Kasar AK et al (2019) Advanced metal matrix nanocomposites

There is also evidence to suggest that they might play a role in improving gut microbiota composition, which is crucial for overall digestive health and has been linked to numerous aspects of metabolic health