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Despite this research, the FDA raises concerns about prescribing off-label GLP-1 medications for prediabetes

Some patients also report withdrawal-like symptoms when stopping semaglutide before starting tirzepatide, though a direct switch typically avoids this issue

Neurology 89(18):19151922 Haidet-Phillips AM, Hester ME, Miranda CJ, Meyer K, Braun L, Frakes A, Song S, Likhite S, Murtha MJ, Foust KD, Rao M (2011) Astrocytes from familial and sporadic ALS patients are toxic to motor neurons

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DermaVue follows a structured titration: 2.5 mg for weeks 1-4, then 5 mg (weeks 5-8), 7.5 mg (weeks 9-12), 10 mg (weeks 13-16), 12.5 mg (weeks 17-20), and 15 mg from week 21 onward