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Plasma levels of GHK-Cu are highest in young adults (approximately 200 ng/mL) and decline significantly with age (dropping to approximately 80 ng/mL by age 60)

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Of note, there are at least five other mechanisms besides secondary neuroinflammation by which COVID can affect the CNS (direct viral invasion of neural tissue, autoimmunity, reactivation of herpesviruses, neurovascular dysfunction, the sequelae of hypoxic, and other metabolic disturbances), which may occur exclusively or in combination in some individuals with varying frequency and timing (for review, see [88])