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The placenta is a highly active metabolic organ
PeruzzoloTLPintoJVRozaTHShintaniAOAnzolinAPGnielkaVet al
Overall, excessive truncation and S129p may create a precarious cellular state, causing widespread and unpredictable cellular consequences by enhancing promiscuous interaction, sequestering essential cellular components, and promoting LB nucleation and growth (Fig
The compound demonstrates exceptional target selectivity, with no inhibition of related methyltransferases (DNMT1, PRMT3, COMT) or NAD+ salvage enzymes (NAMPT, SIRT1) at concentrations up to 600 M
Endocrinology (2003) 144(9):3799810.10.1210/en.2003-0374 252 BartkeAListEOKopchickJJ
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