And like a lot of other GLP-1 patients, Ive been quietly terrified about what that might mean for my muscle
Gastrointestinal effects are experienced by a significant proportion of patients, particularly during dose initiation and escalation: Nausea (affecting up to 20% of patients) is typically most pronounced in the first few weeks and often diminishes with continued use [10] [11] Diarrhoea or constipation may occur as the digestive system adjusts to slower gastric emptying Abdominal discomfort, bloating, or indigestion are common but usually mild Vomiting occurs less frequently but may necessitate dose adjustment These gastrointestinal symptoms can be minimised by eating smaller, more frequent meals, avoiding high-fat foods, and ensuring adequate hydration
Its worth noting that comparing results across weight loss trials can be difficult, since studies often include different patient populations, treatment durations, dosing schedules, and study methods
While individual results vary, many patients experience: Noticeable weight loss within the first month Reduced appetite and fewer cravings Steady, sustainable fat loss (not just water weight) Increased energy and motivation Patients often report better sleep, more consistent moods, and improved confidencebecause when your body starts feeling better, everything else improves too
On the other hand, insulin is a potent stimulant of lipid synthesis, antagonising TG breakdown
