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These findings offer epidemiological support for lifestyle-based interventions that target both movement and micronutrient sufficiency to delay age-related physiological decline (95)

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Its regulation involves a complex interplay among iron metabolism, the cystine/glutamate antiporter (system Xc-)/GSH/GPX4 antioxidant pathway, and lipid peroxidation processes [111]

In order to treat and prevent ROS in gastric cancer, it may be crucial to focus on the enhancement of ROS by neutralizing antioxidants to induce cancer cell death, and the inhibition of ROS activity or increase of antioxidant capacity to regulate pro-tumorigenic signaling pathways