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doi: 10.1161/CIRCULATIONAHA.112.000936 137 PanKLiXChenYZhuDLiYTaoGet al

[14] Local IGF-1 isoforms, mechanical loading, satellite-cell dynamics, and myostatin signaling together form the regulatory web within which any exogenous IGF-1 agonist would be acting another reason that predicting the whole-organism effect of an isolated analog from single-pathway experiments is unreliable

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