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Metaanalysis showed a significantly increased risk of pancreatitis (RR: 1.44, 95% CI 1.091.89, p = 0.009), but not when stratified by background medications (RR: 1.28, 95% CI 0.871.87) and without background medications (RR: 1.37, 95% CI 0.912.05)

RCTs with rigorous lifestyle control [e.g., standardized physical activity protocols] are needed to confirm causal relationships

Maintaining proper storage conditions is essential for ensuring the medication remains stable and suitable for use throughout its beyond-use date

GH-induced increases in IGF-1 are associated with increased muscle protein synthesis and satellite cell activation (Baar, Journal of Applied Physiology )

Nat Rev Neurosci 18: 101-113