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Vitamin B6 & B12 contributes to normal homocysteine metabolism

Although these drugs show beneficial effects, such as somatostatin analogs, which normalize IGF-1 levels in around 45% of treated patients as is the case for lanreotide (269), they have also been reported to inhibit insulin secretion triggering the development of diabetes mellitus and aggravating the insulin resistance found in acromegalic patients (268, 270)

Injectable overdose is theoretically possible but would require dosages hundreds or thousands of times higher than research protocols

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Glia 62 , 14181434 (2014)