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10.1016/j.redox.2022.102363 115 NicholsA

Our objectives were to

Erlotinib versus standard chemotherapy as first-line treatment for European patients with advanced EGFR mutation-positive non-small-cell lung cancer (EURTAC): a multicentre, open-label, randomised Phase 3 trial

The biology is too interconnected, the mechanisms too numerous, and the standard tools too blunt

In the epidermis, ROS induce oxidative DNA lesionsincluding 8-hydroxy-2-deoxyguanosine (8-OHdG) formation, mitochondrial DNA damage, and telomere attritionactivating the p53-p21 pathway and leading keratinocytes toward cell cycle arrest or apoptosis [183, 184]