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While these drugs have shown promise in promoting weight loss, their long-term safety and efficacy for this purpose remain unclear

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Patients with severe gastroparesis, active gallbladder disease, or diabetic retinopathy requiring active treatment should pursue in-person endocrinology care rather than telehealth

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Clinicians monitoring this space should watch for Phase I disclosures of biased GHS-R1a agonists, which would signal the first mechanistic advance beyond ibutamoren's original 1995 discovery 25