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Weight management with GLP-1 medications is typically ongoing
On average, patients using these medications can achieve significant reductions in HbA1c (a marker of blood sugar control) and weight loss of around 314% of their body weight, depending on the medication and lifestyle changes
Ideal Candidates Retatrutide may work best for adults with obesity, which is defined as a BMI of 30 kilograms per square meter or higher, or for those with a BMI over 27 kilograms per square meter who have obesity-related health issues such as type 2 diabetes, high blood pressure, or sleep apnea
The data revealed that while participants treated with semaglutide did lose absolute lean mass, they lost a significantly larger amount of fat mass
GIP is also implicated in nausea attenuation, which may be why GLP-1/GIP dual agonists like tirzepatide have a slightly better GI tolerability profile than pure GLP-1 agonists
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