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Data availability The consensus models and rFASTCORMICS can be downloaded from and Raw FASTQ files were submitted to the European Genome-phenome Archive (EGA) database, accession number: EGAS00001006463

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Further research found that GA can reverse the decline of peroxisome proliferator-activated receptor alpha (PPAR-) and liver X receptor-alpha (LXR-) and the increase of sterol regulatory element-binding protein-1c (SREBP-1c) mRNA caused by HFD by anti-oxidative stress and improving steatopathy, thus alleviating NAFLD ( GA has the potential to alleviate NAFLD via the AMPK pathway, subsequently hindering the progression to hepatitis and cirrhosis, thereby underscoring AMPK as a crucial therapeutic target

Interestingly, recent studies have demonstrated that microglia are resistant to ferroptosis (83, 150)

14 Other major medical organizations do not have any recommendations for screening low-risk patients