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In patients with severe intellectual and motor disability, the level of free carnitine was significantly correlated with the severity of constipation, and was significantly lower in the constipation group than in the non-constipation group

doi:10.1007/s11356-015-5013-6 Azuma T, Arima N, Tsukada A et al (2016) Detection of pharmaceuticals and phytochemicals together with their metabolites in hospital effluents in Japan, and their contribution to sewage treatment plant influents

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Although a nitric oxide synthase (NOS) enzyme, as defined in animal systems, has not been directly identified in higher plants, the presence of NOS homologs has been reported in certain algal species and primitive plant groups (Astier et al