Intermittent fasting: a promising dietary intervention for autoimmune diseases
Tirzepatide was initially approved for type 2 diabetes (Mounjaro), and it is now also approved for long-term weight loss in adults with obesity or overweight with weight-related health conditions (Zepbound)
Met is first metabolized by methionine adenosyltransferase (MAT) to form S-adenosylmethionine (SAMe, which is also abbreviated as AdoMet) (Figure 1)
Adverse Effects Electrolyte imbalance: hypokalemia, hyponatremia, hypocalcemia Dehydration and hypotension Ototoxicity (especially with rapid IV administration or with aminoglycosides) Hyperuricemia may precipitate gout Hyperglycemia (mild) Contraindications Severe electrolyte depletion (e.g., hypokalemia, hyponatremia) Anuria (no urine output) Hypersensitivity to sulfonamides (use with caution) Drug Interactions Aminoglycosides: risk of ototoxicity Digoxin: risk of digoxin toxicity due to hypokalemia NSAIDs: reduce diuretic effect Other antihypertensives: additive hypotensive effects Key Counseling Points Take in the morning to avoid nighttime urination
Chua, M.E., Escusa, K.G., Luna, S., Tapia, L.C., Dofitas, B., & Morales, M
