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On its release, critics hailed its overall presentation and numerous scripted sequences, and it won over 50 PC Game of the Year awards

PMID: 10470368 DOI: 10.1016/s0065-2571(98)00029-6

Nephrol Dial Transplant 25:12571265 Schaefer F, Straube E, Oh J, Mehls O, Mayatepek E (1999) Dialysis in neonates with inborn errors of metabolism

But a separate observational study found people on these drugs had almost double the risk of major depression

The mechanism involves both direct effects on fibroblast activity and modulation of genes involved in extracellular matrix protein synthesis (decorin, glycosaminoglycans, etc.)