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Protein intake timing is critical because IGF-1 activates mTOR, the nutrient-sensing kinase that drives protein synthesis only when sufficient amino acids (particularly leucine at 2.53g per meal) are present to co-activate the pathway without adequate dietary protein, IGF-1 receptor activation occurs but downstream translation of mRNA into new muscle protein is blunted by lack of substrate

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The authors framed the data as first clear evidence that NNMT inhibitors constitute a viable pharmacological approach to enhance regenerative capacity in aged skeletal muscle

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The CNS environment is tightly regulated to prevent poisons and other undesired chemicals from seeping into the parenchymal area