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Metformin treatment with concentrations of 10, 25, and 50 M significantly restored chondrocyte viability suppressed by H 2 O 2 exposure, and 50 M metformin was chosen for further studies (Fig

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It is the main by-product (via biliverdin) from the oxidation and breakdown of the haem moiety arising from red cell destruction (80%) and other proteins, such as myoglobin and catalase (20%), in the reticuloendothelial system tissue of the spleen, bone marrow and so forth

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