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Practical factorssuch as insurance coverage, approved indication (type 2 diabetes vs obesity), drug availability, previous side effects, and co-existing health conditionsusually matter more than subtle mechanistic differences when deciding which medication to use and how aggressively to dose it

Reports of heavy fatigue and flu-like symptoms cluster among users who moved from maximum-dose tirzepatide directly to 4 mg or more of retatrutide

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A substudy within the Phase 2 trial also found that retatrutide reduced liver fat by up to 82% in patients with metabolic dysfunction-associated steatotic liver disease (MASLD), formerly called fatty liver disease

10.1016/j.bbrc.2010.12.131 21 HamalS.CherukuriL.ShaikhK.KinningerA.DoshiJ.BirudarajuD.et al (2020)