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In addition, SCD1 downregulation decreased the expression of p-YAP and caused YAP disassembly in GC cell nuclei, which also attenuated the Hippo pathway activation

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Any perturbation of this balance, caused by excessive production of disulphide bonds during normal protein secretion or the production of mutant misfolded protein, might cause an excess of ROS to accumulate and ultimately lead to cell death

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One year later, the results speak for themselves

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