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In addition to endocrine and reproductive clinical findings, PCOS also leads to consequences on mental health

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Considering that nearly half of all of the dogs recruited for the EPIC Study were cavaliers (161/354 = 45.5%), when these sham echo and x-ray minimum parameters were applied, there was a very real possibility that few or none of them had enlarged hearts at all at the start of the study, and therefore that the EPIC Study was not about dogs with enlarged hearts but just about dogs with MVD murmurs at grade 3 or above