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Humans are funny creatures

The shared pathological foundation of these diseases is immune system dysfunction, resulting in the overproduction of inflammatory mediators, inappropriate activation of immune cells, and ultimately causing tissue damage (4)

Mol Cell Biol, 2010

Binding of C4bp to CSP peptides immobilized to cellulose membrane Since CSP ( Figure 2A ) is the major SPZ surface protein and the main target of the hosts immune response against the pre-erythrocytic stage of the malaria parasite ( via recruiting C4bp to the SPZ surface