Zhao WJ, Hang BJ, Zhu XC, Wang R, Shen MJ, Huang L, Xu ZN (2016) Improving the productivity of S-adenosyl-L-methionine by metabolic engineering in an industrial Saccharomyces cerevisiae strain
The resulting catastrophic energy deficit is a primary physiological driver of post-exertional malaise (PEM) or 'crashes,' where even minor, everyday activities trigger a disproportionate and prolonged exacerbation of profound fatigue, muscle weakness, and cognitive impairment
Rouhier et al
The same people experienced decreases in oxidative stress and increases in glutathione levels after taking antihypertensive medication for 3 months
Additional regulatory considerations involve anti-doping regulations for athletic contexts, though these constraints apply exclusively to competitive sports rather than research environments