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NAD+ PRECURSORS (NMN, NR, NA) Both approaches enhance NAD+-dependent metabolism but through distinct mechanisms: NAD+ precursors (NMN, NR): Provide substrate for NAD+ synthesis, increasing NAD+ production 5-Amino-1MQ: Inhibits NAD+ depletion by suppressing NNMT, preserving existing NAD+ These approaches are mechanistically complementary

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NAD+ is a key player in: Energy Metabolism: It acts as a crucial electron acceptor in metabolic pathways like glycolysis and the Krebs cycle, which are essential for generating adenosine triphosphate (ATP), the primary energy currency of the cell