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A longitudinal analysis

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Typically, it manifests clinically either as solitary or multiple dark melanotic macules (Figure 2a, b) or as diffuse brownish or brown-black areas of melanin hyperpigmentation (Figure 3)

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High doses of ascorbyl palmitate (equivalent to 600 mg/kg of free vitamin C) given concurrently with acetaminophen prevented the elevation of serum liver enzymes in mice and reduced acetaminophen-mediated mortality (Jonker 1988)