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The smaller airways lead down into the alveoli where gas exchange occurs and where surfactants are increasingly required to prevent airway collapse during exhalation (Possmay et al., 2001)

HbA1c fell about 2.0 to 2.6 percentage points and approached its floor by 10 mg, while weight continued responding to higher doses. Participants starting above 8% HbA1c often fell by more than 3 points

[13] DSS Model Results : Weight loss significantly reduced at day 8 Myeloperoxidase activity (neutrophil marker) dropped 50% Prevented colon weight increase and length decrease IL-6 and IL-12 mRNA expression significantly reduced Histology showed less inflammation, reduced cell damage, fewer inflammatory cells in tissue layers TNBS Model Results (more acute inflammation): Weight loss reduced within 1-2 days post-TNBS Colonic MPO activity decreased 30% Prevented TNBS-induced colon shortening Broad cytokine suppression: IL-1, IL-6, TNF-, IFN- mRNA all reduced KPV didnt affect inflammatory markers in healthy mice